I really liked this article on The Geography of Americans who work from Home. I have been doing that for over 15 years and find it very productive. This luxury is possible only in certain industries and for certain types of jobs.
Working from home is more common in knowledge-based metros, being associated with the share of the workforce in knowledge, professional and creative jobs (.37) and even more so with the share of adults that hold college degrees (.50). Working from home is also associated with the concentration of high-tech industry (.34) and levels of innovation (.42, measured as patents per workers). The way workers commute factors in as well.
Whenever I see a trend, I think of product opportunities. I think there are many ways to serve this segment. May be worth doing some research to find out what they are.